Signal transducer and activator of transcription (STAT)

Pathways Recommended:	JAK/STAT Signaling Neuronal Signaling

By Targets:	STAT (8) Akt (1) Apoptosis (5) Bcl-2 Family (1) Keap1-Nrf2 (2) Reactive Oxygen Species (2) Survivin (1)
By Research Areas:	Cancer (7) Neurological Disease (2)

Targets Recommended: STAT ERK OLIG2 ATF6 RUNX Nuclear Factor of activated T Cells (NFAT) Fat Mass and Obesity-associated Protein (FTO) ASK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100602

HJC0152 2 Publications Verification	STAT Apoptosis	Cancer
HJC0152 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.

HY-111152

ML115	STAT	Cancer
ML115 is a molecular probe of the signal transducer and activator of transcription (STAT3). ML115 is a STAT3 agonist .

HY-128588

STAT3-IN-3 Maximum Cited Publications 6 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-3 is a potent and selective inhibitor of **signal transducer and activator of transcription 3 (STAT3)*, with anti-proliferative activity. STAT3-IN-3 induces apoptosis* in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research .

HY-147187

MNK8	STAT Apoptosis Bcl-2 Family Survivin	Cancer
MNK8 is a potent *STAT3* (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells .

HY-N6953

Garcinone D 2 Publications Verification	STAT Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners .

HY-116278

HJC0149	STAT	Cancer
HJC0149 is a potent and orally active inhibitor of signal transducer and activator of **transcription 3 (STAT3)** .

HY-161351

STAT3/AKT-IN-1	Akt STAT Apoptosis	Cancer
STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells .

HY-13559

Atiprimod Azaspirane	Apoptosis	Cancer
Atiprimod (Azaspirane) is an orally bioavailable small molecule with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) by inhibiting the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Atiprimod also downregulates the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the PERK/eIF2α/ATF4/CHOP axis and inhibiting the nuclear translocation of STAT3/NF-κB transcription factors .

HY-N6953R

Garcinone D (Standard)	STAT Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Garcinone D (Standard) is the analytical standard of Garcinone D. This product is intended for research and analytical applications. Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration-and time-dependent manners .

Cat. No.	Product Name

HY-L008

JAK/STAT Compound Library	510 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 510 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

510 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 510 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6953

Garcinone D 2 Publications Verification	Structural Classification Xanthones Guttiferae Source classification Phenols Polyphenols Garcinia mangostana Linn. Plants	STAT Keap1-Nrf2 Reactive Oxygen Species
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners .

HY-N6953R

Garcinone D (Standard)	Structural Classification Xanthones Guttiferae Source classification Phenols Polyphenols Garcinia mangostana Linn. Plants	STAT Keap1-Nrf2 Reactive Oxygen Species
Garcinone D (Standard) is the analytical standard of Garcinone D. This product is intended for research and analytical applications. Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration-and time-dependent manners .

Species:	Human (12)
Tag:	His (11) SUMO (1) Strep (1) Tag Free (1) GST (2)
Source:	Sf9 insect cells (4) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P701098

	STAT3 Protein, Human (Full Length, His) STAT3; Signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and activator of transcription 3; APRF	Human	E. coli
	STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (Full Length, His) is the recombinant human-derived STAT3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of STAT3 Protein, Human (Full Length, His) is 770 a.a., with molecular weight of ~92.1 kDa.

HY-P71337

	STAT6 Protein, Human (His) Signal transducer and activator of transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT6 Protein, Human (His) is 211 a.a..

HY-P76664

	STAT4 Protein, Human (sf9, His) Signal transducer and activator of transcription 4; STAT4	Human	Sf9 insect cells
	The STAT4 protein is mainly expressed in hematopoietic cells and is critical for cell growth, differentiation and immune responses. It plays a key role in T helper 1 cell differentiation, interferon gamma production, and various neutrophil activities. STAT4 Protein, Human (sf9, His) is the recombinant human-derived STAT4 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of STAT4 Protein, Human (sf9, His) is 748 a.a., with molecular weight of ~87 kDa.

HY-P71336

	STAT5B Protein, Human (His) Signal transducer and activator of transcription 5B; STAT5B	Human	E. coli
	The STAT5B protein plays dual roles in signal transduction and transcriptional activation in response to KITLG/SCF and growth factors. STAT5B Protein, Human (His) is the recombinant human-derived STAT5B protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT5B Protein, Human (His) is 321 a.a., with molecular weight of ~38.0 kDa.

HY-P702835A

	STAT6 Protein, Human (536a.a, His) Signal transducer and activator of transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (536a.a, His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with N-His labeled tag.

HY-P70574

	STAT3 Protein, Human (His) Signal transducer and activator of transcription 3; Acute-Phase Response Factor; STAT3; APRF	Human	E. coli
	STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (His) is the recombinant human-derived STAT3 protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT3 Protein, Human (His) is 175 a.a., with molecular weight of 19 & 46 kDa, respectively.

HY-P702835

	STAT6 Protein, Human (Phosphorylated, 536a.a, His) Signal transducer and activator of transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (Phosphorylated, 536a.a, His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with N-His labeled tag.

HY-P703579

	STAT6 Protein, Human (sf9, His, StrepⅡ) Signal transducer and activator of transcription 6; IL-4 Stat; STAT6	Human	Sf9 insect cells
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (sf9, His, Strep) is the recombinant human-derived STAT6 protein, expressed by Sf9 insect cells , with C-His; C-Strep labeled tag.

HY-P73628

	STAT1 Protein, Human (sf9, His-GST) Signal transducer and activator of transcription 1-Alpha/Beta; STAT1	Human	Sf9 insect cells
	STAT1 is a signal transducer and activator of transcription that responds to interferons, KITLG/SCF, and growth factors. After type I IFN binds, STAT1 and STAT2 form ISGF3, which translocates to the nucleus and activates ISG transcription. STAT1 Protein, Human (sf9, His-GST) is the recombinant human-derived STAT1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of STAT1 Protein, Human (sf9, His-GST) is 712 a.a., with molecular weight of ~105 kDa.

HY-P701097

	STAT3 Protein, Human (His-Sumo) Signal transducer and activator of transcription 3; Acute-Phase Response Factor; STAT3; APRF	Human	E. coli
	STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (His-Sumo) is the recombinant human-derived STAT3 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of STAT3 Protein, Human (His-Sumo) is 191 a.a., with molecular weight of ~38.3 kDa.

HY-P73628Y

	STAT1 Protein, Human (sf9, His-GST, solution) Signal transducer and activator of transcription 1-Alpha/Beta; STAT1	Human	Sf9 insect cells
	STAT1 is a signal transducer and activator of transcription that responds to interferons, KITLG/SCF, and growth factors. After type I IFN binds, STAT1 and STAT2 form ISGF3, which translocates to the nucleus and activates ISG transcription. STAT1 Protein, Human (sf9, His-GST, solution) is the recombinant human-derived STAT1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P71335

	STAT1 Protein, Human Signal transducer and activator of transcription 1-Alpha/Beta; transcription Factor ISGF-3 Components p91/p84; STAT1	Human	E. coli
	STAT1 is a signal transducer and activator of transcription that responds to interferons, KITLG/SCF, and growth factors. After type I IFN binds, STAT1 and STAT2 form ISGF3, which translocates to the nucleus and activates ISG transcription. STAT1 Protein, Human is the recombinant human-derived STAT1 protein, expressed by E. coli , with tag free. The total length of STAT1 Protein, Human is 712 a.a., with molecular weight of ~85.0 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80903

	STAT4 Antibody STAT4; Signal transducer and activator of transcription 4	WB, IHC-P, IP	Human
	STAT4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 86 kDa, targeting to STAT4. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human.

HY-P80902

	STAT3 Antibody (YA666) STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor	WB, IHC-P	Human, Rat, Mouse
	STAT3 Antibody (YA666) is a non-conjugated and Mouse origined monoclonal antibody about 88 kDa, targeting to STAT3 (6H10). It can be used for WB,IHC-P assays with tag free, in the background of Human, Rat, Mouse.

HY-P80479

	Phospho-STAT5 (Tyr694) Antibody (YA145) STAT5A; STAT5; Signal transducer and activator of transcription 5A	WB, IHC-P, ICC/IF	Human, Rat, Mouse
	Phospho-Stat5 (Tyr694) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 91 kDa, targeting to Phospho-Stat5(Y694). It can be used for WB,IHC-P,IF-Cell assays with tag free, in the background of Human, Rat, Mouse.

HY-P81768

	Phospho-STAT5(Tyr694) Antibody (YA1513) STAT5A; STAT5; Signal transducer and activator of transcription 5A	WB, IHC-P	Human, Mouse
	Phospho-STAT5(Tyr694) Antibody (YA1513) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1513), targeting Phospho-STAT5(Tyr694), with a predicted molecular weight of 91 kDa . Phospho-STAT5(Tyr694) Antibody (YA1513) can be used for WB, IHC-P experiment in human, mouse background.

HY-P80857

	Phospho-STAT3 (Tyr705) Antibody STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-STAT3 (Tyr705) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 88 kDa, targeting to Phospho-STAT3 (Tyr705). It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80347

	STAT6 Antibody 12S1644 antibody; D12S1644 antibody; IL 4 STAT antibody; IL-4 Stat antibody; IL4 STAT antibody; Interleukin 4 Induced antibody; Interleukin 4 Induced transcription Factor IL4 STAT antibody; Signal transducer and activator of transcription 6 antibody; Signal transducer and activator of transcription 6 Interleukin 4 Induced antibody; Signal transducer and activator of transcription 6 Nirs Variant 1 antibody; Signal transducer and activator of transcription 6, interleukin 4 induced antibody; STAT 6 antibody; STAT interleukin4 induced antibody; STAT, interleukin4 induced antibody; Stat6 antibody; STAT6_HUMAN antibody; STAT6B antibody; STAT6C antibody; transcription factor IL 4 STAT antibody;	WB, ICC/IF, IHC-P, IP	Human, Mouse
	STAT6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 94 kDa, targeting to STAT6. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse.

HY-P80856

	Phospho-STAT1 (Tyr701) Antibody 1 Publications Verification STAT1; Signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84	ICC/IF, WB, IHC-F, IHC-P, IP, ELISA	Human, Mouse, Rat, Monkey
	Phospho-STAT1 (Tyr701) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 87 kDa, targeting to Phospho-STAT1 (Tyr701). It can be used for ICC/IF,WB,IHC-F,IHC-P,IP,ELISA assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P80855

	Phospho-STAT1 (Ser727) Antibody (YA149) STAT1; Signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84	WB, IHC-P	Human, Mouse, Rat
	Phospho-STAT1 (Ser727) Antibody (YA149) is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to Phospho-STAT1 (Ser727). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

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